Cytryn-Silverman (2015:209) suggests that the Umayyad mosque at Tiberias was probably abandoned after suffering partial destruction in the 1068 CE earthquake(s). The collapse debris appears to have been left largely in place, and the surviving northern portion of the building was subsequently reoccupied during the Crusader–Ayyubid period. Occupation continued within the ruined structure itself, with rooms adapted among the collapse deposits and linked by steps that accommodated differing floor levels.

Cytryn (2016:118) reports that the final phase of the building's use as a mosque was Phase IV, an eleventh-century renovation. This phase was dated in part by the recovery of a billon coin of Caliph al-Mustansir Billah (r. 1036–1094 CE) from disturbed fill beneath the latest floor in Square M-21. Cytryn (2016:118) further notes that this plaster floor, which had been laid over a cobblestone bedding layer, exhibited a distinct earthquake-induced crack. The crack cuts the latest floor surface and is considered evidence that the final phase of the mosque was damaged by a seismic event prior to its abandonment.