Ghouta is not a single settlement but a broad agricultural region surrounding Damascus, making it impossible to assign earthquake effects to a single locality within the oasis. Nevertheless, two later Syriac chroniclers, Michael the Syrian and Chronicon Ad Annum 1234, both report exceptionally heavy loss of life in the Ghouta during the earthquake sequence of January 749 CE. These two accounts are not independent, as the Chronicon Ad Annum 1234 and Michael the Syrian are thought to have shared many sources and there are strong similarities in their accounts of this earthquake sequence.

Rather than describing specific collapsed buildings within the oasis, both authors emphasize the human toll, reporting that "myriads" or "countless" people died in the Ghouta. In the same passages they compare this destruction with severe damage reported elsewhere in southwestern Syria, including the collapse of a fortress at Beit Qoubayê in which more than eighty people were killed, strong shaking in Damascus which lasted for days, and the devastation of Bosra, Darayya, and Nawa. Because Ghouta was an extensive rural region rather than a city, the accounts do not identify which villages or structures were affected, only that mortality throughout the oasis was exceptionally high.

The earthquake responsible for the reported destruction cannot be identified with certainty. Because Ghouta lies immediately adjacent to Damascus, the damage most likely resulted from the Holy Desert Quake North, although attribution to the Talking Mule Quake cannot presently be excluded.